, FABIAN PASCHKE, YUEZE GAO, LEONARD-ALEXANDER LIESKE, LENE A. G DDE, STEFANO BARISON, SAMUELE PICCINELLI, ALBERTO BAIARDI, IVANO TAVERNELLI, AND LEO GROS, etc. ▲链接： https://www.science.org/doi/10.1126/science.aea3321 ▲择要： C13Cl2形成一个具备奇异电子布局的应变碳环。这类非平面单重态只有绕环系统四圈后才出现周期性，这与半莫比乌斯拓扑布局相符。 研究者于氯化钠外貌上经由过程脱氯反映合成为了该份子，并使用扫描地道显微镜绘制了其螺旋轨道电子密度漫衍。 他们还有可以或许于这两种具备相反旋转标的目的的半莫比乌斯单重态与平面且拓扑平淡的三重态之间可逆地切换拓扑布局。 ▲ Abstract： C13Cl2 forms a strained ring of carbon atoms with a curious electronic structure. The nonplanar singlet state is periodic only after four circulations of the ring system and is consistent with a half-M bius topology.
et al. synthesized this molecule on a sodium chloride surface by dechlorinating a larger precursor and mapped the helical orbital densities using scanning tunneling microscopy. They could reversibly switch the topology between two singlets of oppositely threaded half-M bius topology and the planar, topologically trivial triplet state. Ferrimagnetism of ultracold fermions in a multiband Hubbard system 多带哈伯德系统中超冷费米子的亚铁磁性 ▲ 作者：MARTIN LEBRAT, ANANT KALE, LEV HALDAR KENDRICK, MUQING XU, YOUQI GANG, ALEXANDER NIKOLAENKO, PIETRO M. BONETTI, SUBIR SACHDEV, AND MARKUS GREINER ▲链接： https://www.science.org/doi/10.1126/science.adq241 ▲择要： 氧化铜超导体和其他强彼此作用系统被认为可以用哈伯德模子来描写。 这一包罗粒子跳跃及彼此作用的模子，可以使用光晶格中的冷原子举行模仿。然而，要纳入多个能带 这对于在正确描写相干物理至关主要，但却十分棘手。 研究者使用光学Lieb晶格中的费米子锂-6原子，对于多带哈伯德模子举行了量子模仿。Lieb晶格可被视为氧化铜晶格的简化描写。因为组成Lieb晶格的两个子格具备不等数目的格点，该系统预期会体现出亚铁磁性。 研究者经由过程自旋的格点分辩丈量不雅察到了这一征象。该要领为摸索奇特物相，如kagome晶格中的量子自旋液体以和近藤模子中的重费米子举动，摊平了门路。 ▲ Abstract： Copper oxide superconductors and other strongly interacting systems are thought to be described by the Hubbard model. This model, which accounts for particle hopping and interactions, can be simulated using cold atoms in optical lattices. However, incorporating multiple energy bands, which is thought to be important for an accurate description of the physics, is tricky. Lebrat et al. performed the quantum simulation of a multiband Hubbard model using fermionic lithium-6 atoms in an optical Lieb lattice, which can be viewed as a simplified description of the copper oxide lattice. Because two the sublattices constituting the Lieb lattice have an unequal number of sites, this system is expected to exhibit ferrimagnetism, which the researchers observed through site-resolved measurements of spin. 生物化学 Biochemistry Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide 生物催化级联反映可实现年夜环肽恩利西肽的制备 ▲ 作者：ARTIS KLAPARS, ANNA FRYSZKOWSKA, STEPHANIE GALANIE, OMER AD, ELLEN Y. AGUILERA, NNAMDI AKPORJI, CHIHUI AN, STEPHANUS AXNANDA, TEWODEROS M. AYELE , AND WENDY ZHONG, etc. ▲链接： https://www.science.org/doi/10.1126/science.aed8713 ▲择要： 汗青上，很多主要的医治靶点仅能经由过程打针给药的生物制剂来靶向。 年夜环肽 例如用在医治动脉粥样硬化性血汗管疾病的前卵白转化酶枯草溶菌素/kexin 9型按捺剂恩利西肽 正最先将这些靶点向口服疗法开放，从而使更多患者可以或许受益。 研究者报导了一种从简朴构建块出发、经由过程会聚式生物催化组装制备恩利西肽的要领。 要领依靠一套工程化酶，以无需掩护基的方式催化选择性肽片断形成、毗连及年夜环化。联合可以或许替换色谱纯化的高效结晶工艺，该要领比拟现有开始进技能将合成步调削减了一半以上，解决了持久存于的合成难题，并为繁杂肽类医治药物的可范围化、可连续开发提供了蓝图。 ▲ Abstract： Historically, many compelling therapeutic targets have been accessible only by injectable biologic drugs. Macrocyclic peptides, such as the proprotein convertase subtilisin/kexin type 9 inhibitor enlicitide for the treatment of atherosclerotic cardiovascular disease, are beginning to unlock these targets to orally administered therapies to enable broader patient access. We report the convergent biocatalytic assembly of enlicitide from simple building blocks enabled by a suite of engineered enzymes to catalyze selective peptide fragment formation, coupling, and macrocyclization in a protecting group free manner. Together with efficient crystallizations that obviate the need for chromatography, this approach reduces the number of steps by greater than half compared with prior state-of-the-art methods, addressing long-standing synthetic challenges and offering a sustainable blueprint for the scalable development of complex peptide therapeutics. 地球物理学 Geophysics Dynamic segmentation of the Sagaing fault 萨冈断层的动态分段特性 ▲ 作者：MINGQI LIU, BINHAO WANG, SEZIM E. GUVERCIN, ZHEN LI, TENG WANG, CHUANJIN LIU, LINGYUN JI, AND SYLVAIN BARBOT ▲链接： https://www.science.org/doi/10.1126/science.ady3237 ▲择要： 一般认为，年夜型走滑断层的滑动受布局界限（如显著弯曲或者岩石类型变化）的限定。 对于在布局相对于简朴的萨冈断层 该断层于2025年曼德勒7.7级地动中发生分裂 其分段性可能更具动态特性。研究则使用2025年分裂事务的卫星数据以和汗青滑动速度，模仿了5000年标准的地动周期。 他们发明，持久滑动速度的变化会影响地动的复发模式。对于在萨冈断层或者圣安德烈斯断层中部等系统而言，持久滑动速度多是节制分段特性及分裂举动的主要因素。 研究突显了整合年夜地丈量、地质及地动学不雅测资料对于在改良地动伤害性评估的主要价值。 ▲ Abstract： Slip along major strike-slip faults is thought to be limited by structural boundaries such as prominent bends or changes in rock type. For the less structurally complex Sagaing fault, which ruptured during the 2025 moment magnitude 7.7 Mandalay event, segmentation may be more dynamic. Liu et al. applied satellite data for the 2025 rupture and also historical slip rates to simulate earthquake cycles over 5000 years. They found that variations in long-term slip rate influenced the recurrence patterns of earthquakes. For systems such as the Sagaing or central San Andreas faults, long-term slip may be an important factor in segmentation and rupture. These results highlight the value of integrating geodetic, geological, and seismological observations to improve seismic hazard assessment.尤其声明：本文转载仅仅是出在流传信息的需要，其实不象征着代表本网站不雅点或者证明其内容的真实性；如其他媒体、网站或者小我私家从本网站转载利用，须保留本网站注明的“来历”，并自大版权等法令责任；作者假如不但愿被转载或者者接洽转载稿费等事宜，请与咱们联系。-PA集团官网"/>
2026-05-29 11:09:11
植物生物多样性
, FABIAN PASCHKE, YUEZE GAO, LEONARD-ALEXANDER LIESKE, LENE A. G DDE, STEFANO BARISON, SAMUELE PICCINELLI, ALBERTO BAIARDI, IVANO TAVERNELLI, AND LEO GROS, etc. ▲链接： https://www.science.org/doi/10.1126/science.aea3321 ▲择要： C13Cl2形成一个具备奇异电子布局的应变碳环。这类非平面单重态只有绕环系统四圈后才出现周期性，这与半莫比乌斯拓扑布局相符。 研究者于氯化钠外貌上经由过程脱氯反映合成为了该份子，并使用扫描地道显微镜绘制了其螺旋轨道电子密度漫衍。 他们还有可以或许于这两种具备相反旋转标的目的的半莫比乌斯单重态与平面且拓扑平淡的三重态之间可逆地切换拓扑布局。 ▲ Abstract： C13Cl2 forms a strained ring of carbon atoms with a curious electronic structure. The nonplanar singlet state is periodic only after four circulations of the ring system and is consistent with a half-M bius topology.
et al. synthesized this molecule on a sodium chloride surface by dechlorinating a larger precursor and mapped the helical orbital densities using scanning tunneling microscopy. They could reversibly switch the topology between two singlets of oppositely threaded half-M bius topology and the planar, topologically trivial triplet state. Ferrimagnetism of ultracold fermions in a multiband Hubbard system 多带哈伯德系统中超冷费米子的亚铁磁性 ▲ 作者：MARTIN LEBRAT, ANANT KALE, LEV HALDAR KENDRICK, MUQING XU, YOUQI GANG, ALEXANDER NIKOLAENKO, PIETRO M. BONETTI, SUBIR SACHDEV, AND MARKUS GREINER ▲链接： https://www.science.org/doi/10.1126/science.adq241 ▲择要： 氧化铜超导体和其他强彼此作用系统被认为可以用哈伯德模子来描写。 这一包罗粒子跳跃及彼此作用的模子，可以使用光晶格中的冷原子举行模仿。然而，要纳入多个能带 这对于在正确描写相干物理至关主要，但却十分棘手。 研究者使用光学Lieb晶格中的费米子锂-6原子，对于多带哈伯德模子举行了量子模仿。Lieb晶格可被视为氧化铜晶格的简化描写。因为组成Lieb晶格的两个子格具备不等数目的格点，该系统预期会体现出亚铁磁性。 研究者经由过程自旋的格点分辩丈量不雅察到了这一征象。该要领为摸索奇特物相，如kagome晶格中的量子自旋液体以和近藤模子中的重费米子举动，摊平了门路。 ▲ Abstract： Copper oxide superconductors and other strongly interacting systems are thought to be described by the Hubbard model. This model, which accounts for particle hopping and interactions, can be simulated using cold atoms in optical lattices. However, incorporating multiple energy bands, which is thought to be important for an accurate description of the physics, is tricky. Lebrat et al. performed the quantum simulation of a multiband Hubbard model using fermionic lithium-6 atoms in an optical Lieb lattice, which can be viewed as a simplified description of the copper oxide lattice. Because two the sublattices constituting the Lieb lattice have an unequal number of sites, this system is expected to exhibit ferrimagnetism, which the researchers observed through site-resolved measurements of spin. 生物化学 Biochemistry Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide 生物催化级联反映可实现年夜环肽恩利西肽的制备 ▲ 作者：ARTIS KLAPARS, ANNA FRYSZKOWSKA, STEPHANIE GALANIE, OMER AD, ELLEN Y. AGUILERA, NNAMDI AKPORJI, CHIHUI AN, STEPHANUS AXNANDA, TEWODEROS M. AYELE , AND WENDY ZHONG, etc. ▲链接： https://www.science.org/doi/10.1126/science.aed8713 ▲择要： 汗青上，很多主要的医治靶点仅能经由过程打针给药的生物制剂来靶向。 年夜环肽 例如用在医治动脉粥样硬化性血汗管疾病的前卵白转化酶枯草溶菌素/kexin 9型按捺剂恩利西肽 正最先将这些靶点向口服疗法开放，从而使更多患者可以或许受益。 研究者报导了一种从简朴构建块出发、经由过程会聚式生物催化组装制备恩利西肽的要领。 要领依靠一套工程化酶，以无需掩护基的方式催化选择性肽片断形成、毗连及年夜环化。联合可以或许替换色谱纯化的高效结晶工艺，该要领比拟现有开始进技能将合成步调削减了一半以上，解决了持久存于的合成难题，并为繁杂肽类医治药物的可范围化、可连续开发提供了蓝图。 ▲ Abstract： Historically, many compelling therapeutic targets have been accessible only by injectable biologic drugs. Macrocyclic peptides, such as the proprotein convertase subtilisin/kexin type 9 inhibitor enlicitide for the treatment of atherosclerotic cardiovascular disease, are beginning to unlock these targets to orally administered therapies to enable broader patient access. We report the convergent biocatalytic assembly of enlicitide from simple building blocks enabled by a suite of engineered enzymes to catalyze selective peptide fragment formation, coupling, and macrocyclization in a protecting group free manner. Together with efficient crystallizations that obviate the need for chromatography, this approach reduces the number of steps by greater than half compared with prior state-of-the-art methods, addressing long-standing synthetic challenges and offering a sustainable blueprint for the scalable development of complex peptide therapeutics. 地球物理学 Geophysics Dynamic segmentation of the Sagaing fault 萨冈断层的动态分段特性 ▲ 作者：MINGQI LIU, BINHAO WANG, SEZIM E. GUVERCIN, ZHEN LI, TENG WANG, CHUANJIN LIU, LINGYUN JI, AND SYLVAIN BARBOT ▲链接： https://www.science.org/doi/10.1126/science.ady3237 ▲择要： 一般认为，年夜型走滑断层的滑动受布局界限（如显著弯曲或者岩石类型变化）的限定。 对于在布局相对于简朴的萨冈断层 该断层于2025年曼德勒7.7级地动中发生分裂 其分段性可能更具动态特性。研究则使用2025年分裂事务的卫星数据以和汗青滑动速度，模仿了5000年标准的地动周期。 他们发明，持久滑动速度的变化会影响地动的复发模式。对于在萨冈断层或者圣安德烈斯断层中部等系统而言，持久滑动速度多是节制分段特性及分裂举动的主要因素。 研究突显了整合年夜地丈量、地质及地动学不雅测资料对于在改良地动伤害性评估的主要价值。 ▲ Abstract： Slip along major strike-slip faults is thought to be limited by structural boundaries such as prominent bends or changes in rock type. For the less structurally complex Sagaing fault, which ruptured during the 2025 moment magnitude 7.7 Mandalay event, segmentation may be more dynamic. Liu et al. applied satellite data for the 2025 rupture and also historical slip rates to simulate earthquake cycles over 5000 years. They found that variations in long-term slip rate influenced the recurrence patterns of earthquakes. For systems such as the Sagaing or central San Andreas faults, long-term slip may be an important factor in segmentation and rupture. These results highlight the value of integrating geodetic, geological, and seismological observations to improve seismic hazard assessment.尤其声明：本文转载仅仅是出在流传信息的需要，其实不象征着代表本网站不雅点或者证明其内容的真实性；如其他媒体、网站或者小我私家从本网站转载利用，须保留本网站注明的“来历”，并自大版权等法令责任；作者假如不但愿被转载或者者接洽转载稿费等事宜，请与咱们联系。-PA集团官网
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